Catalog Number - 68522-05P

68522-05P Cogent RP PFP™ HPLC Column has been a premium value trusted by HPLC laboratories for many years, delivering consistent performance and enhanced selectivity for challenging separations. This column is fully double end‑capped and bonded via a four‑carbon linker to a benzene ring substituted with five fluorine atoms, using ultra‑high purity silica.

The column provides multiple retention mechanisms—including π‑π interactions, dipole interactions, and hydrogen bonding—making it particularly effective for halogenated, aromatic, and polar analytes. It is also suitable as an alternate column for USP methods requiring L43 classification.

With a 5 µm particle size, this column delivers lower backpressure than smaller particle columns, enabling higher flow rates and reliable, robust performance in routine analytical workflows.

50 mm Length – Fast Screening and High Throughput

The 50 mm length is optimized for rapid separations and high‑throughput applications.

• Fast run times for increased sample throughput

• Reduced solvent consumption

• Ideal for method development and screening

✅ Recommended for QA/QC labs and fast analytical workflows

Flow Rate & System Requirements (4.6 mm ID, 5 µm)

⚠️ Fully compatible with standard analytical HPLC systems with low backpressure

• Typical flow rate range: ~1.0 – 2.0 mL/min

• Lower backpressure than 3 µm columns

• Supports higher flow rates for faster analysis

• Compatible with UV and standard detectors

✅ Best Practice: Filter samples using a 0.2 µm syringe filter prior to injection

Why Choose PFP (F5) Columns for Selective Separations

Enhanced Retention for Halogenated Compounds

• Strong interaction with fluorinated and halogenated analytes

• Improved selectivity vs C18 columns

Multiple Interaction Mechanisms

• π‑π interactions for aromatic compounds

• Dipole and hydrogen bonding interactions

• Greater flexibility for method development

100 Å Pore Structure

• Suitable for small to moderately sized molecules

• Broader application range vs lower pore sizes

Cogent RP PFP™ Column Advantages

Fully End‑Capped Surface

• Minimizes silanol activity

• Improves peak symmetry

Robust Performance (5 µm Particles)

• Lower backpressure compared to smaller particle sizes

• Reliable and consistent operation

High Purity Silica

• Reproducible chromatographic performance

• Long column lifetime

Typical Applications

• Halogenated compound screening

• Aromatic compound separations

• Rapid analytical workflows

• Method development and optimization

• USP L43 methods

Important Usage Notes

• Packed and shipped in reversed‑phase solvents

• Designed for standard analytical HPLC systems (4.6 mm ID)

• Lower backpressure compared to smaller particle sizes

• Use 0.2 µm filtration prior to injection